Large systematic review of antidepressants
In 194 head-to-head RCTs, agomelatine, amitriptyline, escitalopram, mirtazapine, paroxetine, venlafaxine and vortioxetine were more effective than other antidepressants, whereas fluoxetine, fluvoxamine, reboxetine, and trazodone were the least effective. Agomelatine, citalopram, escitalopram, fluoxetine, sertraline and vortioxetine were better tolerated than others. Amitriptyline, clomipramine, duloxetine, fluvoxamine, reboxetine, trazodone and venlafaxine were associated…
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